abstract：:Little is known about the specificities and neutralization breadth of the H7-reactive antibody repertoire induced by natural H7N9 infection in humans. We have isolated and characterized 73 H7-reactive monoclonal antibodies from peripheral B cells from four donors infected in 2013 and 2014. Of these, 45 antibodies were...

journal_title：Nature microbiology

authors： Huang KA,Rijal P,Jiang H,Wang B,Schimanski L,Dong T,Liu YM,Chang P,Iqbal M,Wang MC,Chen Z,Song R,Huang CC,Yang JH,Qi J,Lin TY,Li A,Powell TJ,Jan JT,Ma C,Gao GF,Shi Y,Townsend AR

更新日期：2019-02-01 00:00:00

abstract：:Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) ag...

journal_title：Nature microbiology

authors： Kim AS,Austin SK,Gardner CL,Zuiani A,Reed DS,Trobaugh DW,Sun C,Basore K,Williamson LE,Crowe JE Jr,Slifka MK,Fremont DH,Klimstra WB,Diamond MS

更新日期：2019-01-01 00:00:00

abstract：:Competition among microorganisms is a key determinant of successful host colonization and persistence. For Streptococcus pneumoniae, lower than predicted rates of co-colonizing strains suggest a competitive advantage for resident bacteria over newcomers. In light of evolutionary theory, we hypothesized that S. pneumon...

journal_title：Nature microbiology

authors： Shen P,Lees JA,Bee GCW,Brown SP,Weiser JN

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors：

更新日期：2018-12-01 00:00:00

abstract：:Host factors that silence provirus transcription in CD4+ memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs1. These same factors, however, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency viruses activate provi...

journal_title：Nature microbiology

authors： Yurkovetskiy L,Guney MH,Kim K,Goh SL,McCauley S,Dauphin A,Diehl WE,Luban J

更新日期：2018-12-01 00:00:00

abstract：:Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection1. The activities of bacterial effectors and their associated roles within the host cell are often poorly understood, particularly for Chlamydia trachomatis2, a World Health Organization designated neglec...

journal_title：Nature microbiology

authors： Pruneda JN,Bastidas RJ,Bertsoulaki E,Swatek KN,Santhanam B,Clague MJ,Valdivia RH,Urbé S,Komander D

更新日期：2018-12-01 00:00:00

abstract：:Immune responses in insects are differentially triggered depending on the infection route used by the pathogen. In most studies involving Drosophila melanogaster and viruses, infection is done by injection, while oral infection, which is probably the most common route of viral entry in nature, remains unexplored. Here...

journal_title：Nature microbiology

authors： Mondotte JA,Gausson V,Frangeul L,Blanc H,Lambrechts L,Saleh MC

更新日期：2018-12-01 00:00:00

abstract：:Glycans are major nutrients for the human gut microbiota (HGM). Arabinogalactan proteins (AGPs) comprise a heterogenous group of plant glycans in which a β1,3-galactan backbone and β1,6-galactan side chains are conserved. Diversity is provided by the variable nature of the sugars that decorate the galactans. The mecha...

journal_title：Nature microbiology

authors： Cartmell A,Muñoz-Muñoz J,Briggs JA,Ndeh DA,Lowe EC,Baslé A,Terrapon N,Stott K,Heunis T,Gray J,Yu L,Dupree P,Fernandes PZ,Shah S,Williams SJ,Labourel A,Trost M,Henrissat B,Gilbert HJ

更新日期：2018-11-01 00:00:00

abstract：: ...

journal_title：Nature microbiology

authors： Francetic O

更新日期：2018-11-01 00:00:00

abstract：:The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a strong innate immune dysregulation known as 'cytokine storm' contributes to the pathology of ...

journal_title：Nature microbiology

authors： Te Velthuis AJW,Long JC,Bauer DLV,Fan RLY,Yen HL,Sharps J,Siegers JY,Killip MJ,French H,Oliva-Martín MJ,Randall RE,de Wit E,van Riel D,Poon LLM,Fodor E

更新日期：2018-11-01 00:00:00

abstract：:Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved to become a formidable nosocomial pathogen. Using genomics, we reveal that three multidrug-resistant, hospital-adapted lineages of S. epidermidis (two ST2 and on...

journal_title：Nature microbiology

authors： Lee JYH,Monk IR,Gonçalves da Silva A,Seemann T,Chua KYL,Kearns A,Hill R,Woodford N,Bartels MD,Strommenger B,Laurent F,Dodémont M,Deplano A,Patel R,Larsen AR,Korman TM,Stinear TP,Howden BP

更新日期：2018-10-01 00:00:00

abstract：:The dysregulation of intestinal microbial communities is associated with inflammatory bowel diseases (IBD). Studies aimed at understanding the contribution of the microbiota to inflammatory diseases have primarily focused on bacteria, yet the intestine harbours a viral component dominated by prokaryotic viruses known ...

journal_title：Nature microbiology

authors： Duerkop BA,Kleiner M,Paez-Espino D,Zhu W,Bushnell B,Hassell B,Winter SE,Kyrpides NC,Hooper LV

更新日期：2018-09-01 00:00:00

abstract：:How does knowing the evolutionary history of microorganisms affect our analysis of microbiological datasets? Depending on the research question, the common ancestry of microorganisms can be a source of confounding variation, or a scaffolding used for inference. For example, when performing regression on traits, common...

journal_title：Nature microbiology

authors： Washburne AD,Morton JT,Sanders J,McDonald D,Zhu Q,Oliverio AM,Knight R

更新日期：2018-06-01 00:00:00

abstract：:Crimean-Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe 1 . Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid t...

journal_title：Nature microbiology

authors： Haddock E,Feldmann F,Hawman DW,Zivcec M,Hanley PW,Saturday G,Scott DP,Thomas T,Korva M,Avšič-Županc T,Safronetz D,Feldmann H

更新日期：2018-05-01 00:00:00

abstract：:Zika virus (ZIKV) is associated with neonatal microcephaly and Guillain-Barré syndrome1,2. While progress has been made in understanding the causal link between ZIKV infection and microcephaly3-9, the life cycle and pathogenesis of ZIKV are less well understood. In particular, there are conflicting reports on the role...

journal_title：Nature microbiology

authors： Chen J,Yang YF,Yang Y,Zou P,Chen J,He Y,Shui SL,Cui YR,Bai R,Liang YJ,Hu Y,Jiang B,Lu L,Zhang X,Liu J,Xu J

更新日期：2018-03-01 00:00:00

abstract：:In the version of this Perspective originally published, the first and last name of co-author Manimozhiyan Arumugam were switched. This has now been corrected in all versions of the Perspective. ...

journal_title：Nature microbiology

authors： Costea PI,Hildebrand F,Arumugam M,Bäckhed F,Blaser MJ,Bushman FD,de Vos WM,Ehrlich SD,Fraser CM,Hattori M,Huttenhower C,Jeffery IB,Knights D,Lewis JD,Ley RE,Ochman H,O'Toole PW,Quince C,Relman DA,Shanahan F,Sunaga

更新日期：2018-03-01 00:00:00

abstract：:The original version of this Letter has been modified in the abstract and main text to better reflect the distribution of Neu5Ac sialoglycans in humans. Additionally, co-author Lingquan Deng's present address has been further clarified. ...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:The evolution of virulence traits is central for the emergence or re-emergence of microbial pathogens and for their adaptation to a specific host 1-5 . Typhoid toxin is an essential virulence factor of the human-adapted bacterial pathogen Salmonella Typhi 6,7 , the cause of typhoid fever in humans 8-12 . Typhoid toxin...

journal_title：Nature microbiology

authors： Gao X,Deng L,Stack G,Yu H,Chen X,Naito-Matsui Y,Varki A,Galán JE

更新日期：2017-12-01 00:00:00

abstract：:The microbial environment influences animal physiology. However, the underlying molecular mechanisms of such functional interactions are largely undefined. Previously, we showed that during chronic undernutrition, strains of Lactobacillus plantarum, a major commensal partner of Drosophila, promote host juvenile growth...

journal_title：Nature microbiology

authors： Matos RC,Schwarzer M,Gervais H,Courtin P,Joncour P,Gillet B,Ma D,Bulteau AL,Martino ME,Hughes S,Chapot-Chartier MP,Leulier F

更新日期：2017-12-01 00:00:00

abstract：:Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM) proteins are important regulators of both processes. Although the role of TRIM proteins in modulating antiviral cytokine responses has been well established, muc...

journal_title：Nature microbiology

authors： Sparrer KMJ,Gableske S,Zurenski MA,Parker ZM,Full F,Baumgart GJ,Kato J,Pacheco-Rodriguez G,Liang C,Pornillos O,Moss J,Vaughan M,Gack MU

更新日期：2017-11-01 00:00:00

abstract：:Mosquito-borne viruses can cause severe inflammatory diseases and there are limited therapeutic solutions targeted specifically at virus-induced inflammation. Chikungunya virus (CHIKV), a re-emerging alphavirus responsible for several outbreaks worldwide in the past decade, causes debilitating joint inflammation and s...

journal_title：Nature microbiology

authors： Chen W,Foo SS,Zaid A,Teng TS,Herrero LJ,Wolf S,Tharmarajah K,Vu LD,van Vreden C,Taylor A,Freitas JR,Li RW,Woodruff TM,Gordon R,Ojcius DM,Nakaya HI,Kanneganti TD,O'Neill LAJ,Robertson AAB,King NJ,Suhrbier A,Coope

更新日期：2017-10-01 00:00:00

abstract：:The core properties of microbial genomes, including GC content and genome size, are known to vary widely among different bacteria and archaea 1,2 . Several hypotheses have been proposed to explain this genomic variability, but the fundamental drivers that shape bacterial and archaeal genomic properties remain uncertai...

journal_title：Nature microbiology

authors： Mende DR,Bryant JA,Aylward FO,Eppley JM,Nielsen T,Karl DM,DeLong EF

更新日期：2017-10-01 00:00:00

abstract：:The temporal dynamics of phytoplankton growth and activity have large impacts on fluxes of matter and energy, yet obtaining in situ metabolic measurements of sufficient resolution for even dominant microorganisms remains a considerable challenge. We performed Lagrangian diel sampling with synoptic measurements of popu...

journal_title：Nature microbiology

authors： Wilson ST,Aylward FO,Ribalet F,Barone B,Casey JR,Connell PE,Eppley JM,Ferrón S,Fitzsimmons JN,Hayes CT,Romano AE,Turk-Kubo KA,Vislova A,Armbrust EV,Caron DA,Church MJ,Zehr JP,Karl DM,DeLong EF

更新日期：2017-07-31 00:00:00

abstract：:Surface ocean waters are dominated by planktonic bacterial lineages with highly reduced genomes. The best examples are the cyanobacterial genus Prochlorococcus, the alphaproteobacterial clade SAR11 and the gammaproteobacterial clade SAR86, which together represent over 50% of the cells in surface oceans. Several studi...

journal_title：Nature microbiology

authors： Luo H,Huang Y,Stepanauskas R,Tang J

更新日期：2017-06-12 00:00:00

abstract：:This corrects the article DOI: 10.1038/nmicrobiol.2016.155. ...

journal_title：Nature microbiology

authors： Buffalo CZ,Bahn-Suh AJ,Hirakis SP,Biswas T,Amaro RE,Nizet V,Ghosh P

更新日期：2017-06-12 00:00:00

abstract：:Many animal viruses are enveloped in a lipid bilayer taken up from cellular membranes. Because viral surface proteins bind to these membranes to initiate infection, we hypothesized that free virions may also be capable of interacting with the envelopes of other virions extracellularly. Here, we demonstrate this hypoth...

journal_title：Nature microbiology

authors： Cuevas JM,Durán-Moreno M,Sanjuán R

更新日期：2017-05-22 00:00:00

abstract：:Coenzymes are vital for cellular metabolism and act on the full spectrum of enzymatic reactions. Intrinsic chemical reactivity, enzyme promiscuity and high flux through their catalytic cycles make coenzymes prone to damage. To counteract such compromising factors and ensure stable levels of functional coenzymes, cells...

journal_title：Nature microbiology

authors： Hartl J,Kiefer P,Meyer F,Vorholt JA

更新日期：2017-05-15 00:00:00

abstract：:Many insects, including mosquitoes, planthoppers, aphids and leafhoppers, are the hosts of bacterial symbionts and the vectors for transmitting viral pathogens1-3. In general, symbiotic bacteria can indirectly affect viral transmission by enhancing immunity and resistance to viruses in insects3-5. Whether symbiotic ba...

journal_title：Nature microbiology

authors： Jia D,Mao Q,Chen Y,Liu Y,Chen Q,Wu W,Zhang X,Chen H,Li Y,Wei T

更新日期：2017-03-06 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular ...

journal_title：Nature microbiology

authors： Soonthornvacharin S,Rodriguez-Frandsen A,Zhou Y,Galvez F,Huffmaster NJ,Tripathi S,Balasubramaniam VR,Inoue A,de Castro E,Moulton H,Stein DA,Sánchez-Aparicio MT,De Jesus PD,Nguyen Q,König R,Krogan NJ,García-Sastre A,Yoh

更新日期：2017-03-01 00:00:00

abstract：:Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Most cancers develop following random somatic alterations of key oncogenic genes, which are favoured by a number of risk factors, including lifestyle, ...

journal_title：Nature microbiology

authors： Tsilimigras MC,Fodor A,Jobin C

更新日期：2017-02-22 00:00:00

abstract：:Dimethylsulfoniopropionate (DMSP) is one of the Earth's most abundant organosulfur molecules, a signalling molecule1, a key nutrient for marine microorganisms2,3 and the major precursor for gaseous dimethyl sulfide (DMS). DMS, another infochemical in signalling pathways4, is important in global sulfur cycling2 and aff...

journal_title：Nature microbiology

authors： Curson AR,Liu J,Bermejo Martínez A,Green RT,Chan Y,Carrión O,Williams BT,Zhang SH,Yang GP,Bulman Page PC,Zhang XH,Todd JD

更新日期：2017-02-13 00:00:00

abstract：:The development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered and scalable platform for regulated gene si...

journal_title：Nature microbiology

authors： Rock JM,Hopkins FF,Chavez A,Diallo M,Chase MR,Gerrick ER,Pritchard JR,Church GM,Rubin EJ,Sassetti CM,Schnappinger D,Fortune SM

更新日期：2017-02-06 00:00:00

abstract：:Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members of the human gut microbiome. This decrease sensitizes bacteria toward...

journal_title：Nature microbiology

authors： Dahl JU,Gray MJ,Bazopoulou D,Beaufay F,Lempart J,Koenigsknecht MJ,Wang Y,Baker JR,Hasler WL,Young VB,Sun D,Jakob U

更新日期：2017-01-23 00:00:00

abstract：:Legionella pneumophila, the causative bacterium for Legionnaires' disease, hijacks host membrane trafficking for the maturation of the Legionella-containing vacuole (LCV). The LCV membrane mainly contains PtdIns4P, which is important for anchoring many secreted Legionella effectors onto the LCV. Here, we identify a cr...

journal_title：Nature microbiology

authors： Dong N,Niu M,Hu L,Yao Q,Zhou R,Shao F

更新日期：2016-12-12 00:00:00

abstract：:As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We...

journal_title：Nature microbiology

authors： Ballou ER,Avelar GM,Childers DS,Mackie J,Bain JM,Wagener J,Kastora SL,Panea MD,Hardison SE,Walker LA,Erwig LP,Munro CA,Gow NA,Brown GD,MacCallum DM,Brown AJ

更新日期：2016-12-12 00:00:00

abstract：:Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge ...

journal_title：Nature microbiology

authors： Cotton JA,Bennuru S,Grote A,Harsha B,Tracey A,Beech R,Doyle SR,Dunn M,Hotopp JC,Holroyd N,Kikuchi T,Lambert O,Mhashilkar A,Mutowo P,Nursimulu N,Ribeiro JM,Rogers MB,Stanley E,Swapna LS,Tsai IJ,Unnasch TR,Voronin

更新日期：2016-11-21 00:00:00

abstract：:Although bacteria within the Verrucomicrobia phylum are pervasive in soils around the world, they are under-represented in both isolate collections and genomic databases. Here, we describe a single verrucomicrobial group within the class Spartobacteria that is not closely related to any previously described taxa. We e...

journal_title：Nature microbiology

authors： Brewer TE,Handley KM,Carini P,Gilbert JA,Fierer N

更新日期：2016-10-31 00:00:00

abstract：:In structured environments, antibiotic-producing microorganisms can gain a selective advantage by inhibiting nearby competing species1. However, despite their genetic potential2,3, natural isolates often make only small amounts of antibiotics, and laboratory evolution can lead to loss rather than enhancement of antibi...

journal_title：Nature microbiology

authors： Gerardin Y,Springer M,Kishony R

更新日期：2016-09-26 00:00:00

abstract：:Aichi virus (AiV), an unusual and poorly characterized picornavirus, classified in the genus Kobuvirus, can cause severe gastroenteritis and deaths in children below the age of five years, especially in developing countries1,2. The seroprevalence of AiV is approximately 60% in children under the age of ten years and r...

journal_title：Nature microbiology

authors： Zhu L,Wang X,Ren J,Kotecha A,Walter TS,Yuan S,Yamashita T,Tuthill TJ,Fry EE,Rao Z,Stuart DI

更新日期：2016-09-05 00:00:00

abstract：:In most Gram-negative pathogens, the hydrolysis of UDP-2,3-diacylglucosamine to generate lipid X in lipid A biosynthesis is catalysed by the membrane-associated enzyme LpxH. We report the crystal structure of LpxH in complex with its product, lipid X, unveiling a unique insertion lid above the conserved architecture o...

journal_title：Nature microbiology

authors： Cho J,Lee CJ,Zhao J,Young HE,Zhou P

更新日期：2016-08-15 00:00:00